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1

Poliflexsol polyester resin: It's properties and applications to conservation

Shashoua, Yvonne, Wills, Barbara

Journal:

The Conservator

Year:

1994

Language:

english

File:

PDF, 592 KB

english, 1994

2

Toxicology Strategies for Drug Discovery—Present and Future

Blomme, Eric, Will, Yvonne

Journal:

Chemical Research in Toxicology

Year:

2015

Language:

english

File:

PDF, 2.29 MB

english, 2015

3

Toxicology Strategies for Drug Discovery - Present and Future: Introduction

Humphreys, W. Griffith, Will, Yvonne, Guengerich, F. Peter

Journal:

Chemical Research in Toxicology

Year:

2016

Language:

english

File:

PDF, 128 KB

english, 2016

4

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

Nadanaciva, Sashi, Aleo, Michael D., Strock, Christopher J., Stedman, Donald B., Wang, Huijun, Will, Yvonne

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 356 KB

english, 2013

5

[IEEE Fifth European Conference on Web Services (ECOWS'07) - Halle, Germany (2007.11.26-2007.11.28)] Fifth European Conference on Web Services (ECOWS'07) - The Service Responsibility and Interaction Design Method: Using an Agile Approach for Web Service Design

Millard, David E., Davis, Hugh C., Howard, Yvonne, Gilbert, Lester, Walters, Robert J., Abbas, Noura, Wills, Gary B.

Year:

2007

Language:

english

File:

PDF, 632 KB

english, 2007

6

New Insights in Drug-Induced Mitochondrial Toxicity

Nadanaciva, Sashi, Will, Yvonne

Journal:

Current Pharmaceutical Design

Year:

2011

Language:

english

File:

PDF, 192 KB

english, 2011

7

Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective

Butler, Lynne D., Guzzie-Peck, Peggy, Hartke, James, Bogdanffy, Matthew S., Will, Yvonne, Diaz, Dolores, Mortimer-Cassen, Elisabeth, Derzi, Mazin, Greene, Nigel, DeGeorge, Joseph J.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

8

[Methods in Pharmacology and Toxicology] Drug-Induced Liver Toxicity || Translational and Mechanistic Biomarkers of Drug-Induced Liver Injury – Candidates and Qualification Strategies

Chen, Minjun, Will, Yvonne

Year:

2018

Language:

english

File:

PDF, 315 KB

english, 2018

9

γ-Glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses

B. Paige Lawrence, Yvonne Will, Donald J. Reed, Nancy I. Kerkvliet

Journal:

European Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 181 KB

english, 2000

10

Experimental duck hepatitis B virus infection: Pathology and evolution of hepatic and extrahepatic infection

John S. Freiman, Allison R. Jilbert, Robert J. Dixon, Marlis Holmes, Eric J. Gowans, Christopher J. Burrell, Edward J. Wills, Yvonne E. Cossart

Journal:

Year:

1988

Language:

english

File:

PDF, 1.07 MB

english, 1988

11

INSL3 has tumor-promoting activity in thyroid cancer

Sabine Hombach-Klonisch, Joanna Bialek, Yvonne Radestock, Anne Truong, Alexander I. Agoulnik, Barbara Fiebig, Cornelia Willing, Ekkehard Weber, Cuong Hoang-Vu, Thomas Klonisch

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

12

In vitro analysis of cell metabolism using a long-decay pH-sensitive lanthanide probe and extracellular acidification assay

James Hynes, Tomás C. O’Riordan, Alexander V. Zhdanov, Georg Uray, Yvonne Will, Dmitri B. Papkovsky

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 637 KB

english, 2009

13

Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

Nigel Greene, Michael D. Aleo, Shirley Louise-May, David A. Price, Yvonne Will

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 349 KB

english, 2010

14

Data analysis algorithm for high throughput enzymatic oxygen consumption assays based on quenched-fluorescence detection

Vladimir I. Ogurtsov, James Hynes, Yvonne Will, Dmitri B. Papkovsky

Journal:

Sensors and Actuators B: Chemical

Year:

2008

Language:

english

File:

PDF, 932 KB

english, 2008

15

The hydrolysis of glycerol-3-phosphate into glycerol in cardiac tissue: possible consequences for the validity of glycerol release as a measure of lipolysis

Monique J. M. Groot, Yvonne F. Jong, Will A. Coumans, Ger J. Vusse

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1994

Language:

english

File:

PDF, 676 KB

english, 1994

16

The influence of lactate, pyruvate and glucose as exogenous substrates on free radical defense mechanisms in isolated rat hearts during ischaemia and reperfusion

Monique J. M. Groot, Mireille A. B. Helden, Yvonne F. Jong, Will A. Coumans, Ger J. Vusse

Journal:

Molecular and Cellular Biochemistry

Year:

1995

Language:

english

File:

PDF, 952 KB

english, 1995

17

Pragmatic web service design: An agile approach with the service responsibility and interaction design method

David E. Millard, Yvonne Howard, Noura Abbas, Hugh C. Davis, Lester Gilbert, Gary B. Wills, Robert J. Walters

Journal:

Computer Science - Research and Development

Year:

2009

Language:

english

File:

PDF, 928 KB

english, 2009

18

Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes

Will, Yvonne, Hynes, James, Ogurtsov, Vladimir I, Papkovsky, Dmitri B

Journal:

Nature Protocols

Year:

2007

Language:

english

File:

PDF, 303 KB

english, 2007

19

Toward the Molecular Flashlight: Preparation, Properties, and Photophysics of a Hypericin–luciferin Tethered Molecule

Jin Wen, Pramit Chowdhury, Nick J. Wills, Yvonne Wannemuehler, Jaehun Park, Sarathy Kesavan, S. Carpenter, G. A. Kraus, J. W. Petrich

Journal:

Photochemistry and Photobiology

Year:

2002

Language:

english

File:

PDF, 135 KB

english, 2002

20

γ-Glutamyltranspeptidase–Deficient Knockout Mice as a Model to Study the Relationship Between Glutathione Status, Mitochondrial Function, and Cellular Function

Yvonne Will, Kay A Fischer, Robert A Horton, Rhonda S Kaetzel, Marda K Brown, Olaf Hedstrom, Michael W Lieberman, Donald J Reed

Journal:

Year:

2000

Language:

english

File:

PDF, 1.08 MB

english, 2000

21

Effects of high variance of fracture transmissivity on transport and sorption at different scales in a discrete model for fractured rocks

A.Wille Nordqvist, Yvonne W. Tsang, Chin-Fu Tsang, Björn Dverstorp, Johan Andersson

Journal:

Journal of Contaminant Hydrology

Year:

1996

Language:

english

File:

PDF, 1.79 MB

english, 1996

22

The significance of mitochondrial toxicity testing in drug development

James A. Dykens, Yvonne Will

Journal:

Drug Discovery Today

Year:

2007

Language:

english

File:

PDF, 869 KB

english, 2007

23

Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis

Sashi Nadanaciva, John H. Willis, Melissa L. Barker, Dima Gharaibeh, Roderick A. Capaldi, Michael F. Marusich, Yvonne Will

Journal:

Journal of Immunological Methods

Year:

2009

Language:

english

File:

PDF, 1021 KB

english, 2009

24

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration

Sashi Nadanaciva, James A. Dykens, Autumn Bernal, Roderick A. Capaldi, Yvonne Will

Journal:

Toxicology and Applied Pharmacology

Year:

2007

Language:

english

File:

PDF, 1.09 MB

english, 2007

25

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

James A. Dykens, Joseph Jamieson, Lisa Marroquin, Sashi Nadanaciva, Puja A. Billis, Yvonne Will

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

26

Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells

Yi Luo, Payal Rana, Yvonne Will

Journal:

Toxicology and Applied Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

27

Conjugative metabolism of 1,2-dibromoethane in mitochondria: disruption of oxidative phosphorylation and alkylation of mitochondrial DNA

Carin Thomas, Yvonne Will, Saundra L. Schoenberg, Dawn Sanderlin, Donald J. Reed

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 281 KB

english, 2001

28

Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

Wager, Travis T., Chandrasekaran, Ramalakshmi Y., Hou, Xinjun, Troutman, Matthew D., Verhoest, Patrick R., Villalobos, Anabella, Will, Yvonne

Journal:

ACS Chemical Neuroscience

Year:

2010

Language:

english

File:

PDF, 3.68 MB

english, 2010

29

In Vivo Reversal of Glutathione Deficiency and Susceptibility to in Vivo Dexamethasone-Induced Apoptosis by N-Acetylcysteine and l-2-Oxothiazolidine- 4-carboxylic Acid, but Not Ascorbic Acid, in Thymocytes from γ-Glutamyltranspeptidase-Deficient Knockout Mice

Yvonne Will, Rhonda S. Kaetzel, Marda K. Brown, Tamara S. Fraley, Donald J. Reed

Journal:

Archives of Biochemistry and Biophysics

Year:

2002

Language:

english

File:

PDF, 132 KB

english, 2002

30

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays

Sashi Nadanaciva, Autumn Bernal, Robert Aggeler, Roderick Capaldi, Yvonne Will

Journal:

Toxicology in Vitro

Year:

2007

Language:

english

File:

PDF, 710 KB

english, 2007

31

Mitochondrial membrane potential measurement of H9c2 cells grown in high-glucose and galactose-containing media does not provide additional predictivity towards mitochondrial assessment

Payal Rana, Sashi Nadanaciva, Yvonne Will

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

32

A high content screening assay for identifying lysosomotropic compounds

Sashi Nadanaciva, Shuyan Lu, David F. Gebhard, Bart A. Jessen, William D. Pennie, Yvonne Will

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 846 KB

english, 2011

33

The contribution of physicochemical properties to multiple in vitro cytotoxicity endpoints

Shuyan Lu, Bart Jessen, Christopher Strock, Yvonne Will

Journal:

Toxicology in Vitro

Year:

2012

Language:

english

File:

PDF, 677 KB

english, 2012

34

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

Thomas, Craig E, Will, Yvonne

Journal:

Expert Opinion on Drug Discovery

Year:

2012

Language:

english

File:

PDF, 354 KB

english, 2012

35

Solar Irradiance Models and Measurements: A Comparison in the 220–240

Yvonne C. Unruh, Will T. Ball, Natalie A. Krivova

Journal:

Surveys in Geophysics

Year:

2012

Language:

english

File:

PDF, 323 KB

english, 2012

36

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

Sashi Nadanaciva, Payal Rana, Gyda C. Beeson, Denise Chen, David A. Ferrick, Craig C. Beeson, Yvonne Will

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2012

Language:

english

File:

PDF, 485 KB

english, 2012

37

S12.7 The use of oxygen and pH-sensitive fluorescent probes for the investigation of perturbed cell metabolism

James Hynes, Tomas O'Riordan, Dmitri Papkovsky, Yvonne Will

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

38

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

Claudia V. Pereira, Paulo J. Oliveira, Yvonne Will, Sashi Nadanaciva

Journal:

Toxicology and Applied Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

39

The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo

Pereira, Claudia V, Nadanaciva, Sashi, Oliveira, Paulo J, Will, Yvonne

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2012

Language:

english

File:

PDF, 598 KB

english, 2012

40

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

Hynes, James, Nadanaciva, Sashi, Swiss, Rachel, Carey, Conn, Kirwan, Sinead, Will, Yvonne

Journal:

Toxicology in Vitro

Year:

2013

Language:

english

File:

PDF, 531 KB

english, 2013

41

Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death

Swiss, Rachel, Niles, Andrew, Cali, James J., Nadanaciva, Sashi, Will, Yvonne

Journal:

Toxicology in Vitro

Year:

2013

Language:

english

File:

PDF, 470 KB

english, 2013

42

Chemical motifs that redox cycle and their associated toxicity

Rana, Payal, Naven, Russell, Narayanan, Arjun, Will, Yvonne, Jones, Lyn H.

Journal:

Year:

2013

Language:

english

File:

PDF, 248 KB

english, 2013

43

Drug-Induced Mitochondrial Dysfunction || Frontmatter

Dykens, James A., Will, Yvonne

Year:

2008

Language:

english

File:

PDF, 162 KB

english, 2008

44

Drug-Induced Mitochondrial Dysfunction || Assessment of Mitochondrial Respiratory Complex Function in Vitro and in Vivo

Dykens, James A., Will, Yvonne

Year:

2008

Language:

english

File:

PDF, 215 KB

english, 2008

45

Improving the Odds of Success in Drug Discovery: Choosing the Best Compounds for in Vivo Toxicology Studies

Wager, Travis T., Kormos, Bethany L., Brady, Joseph T., Will, Yvonne, Aleo, Michael D., Stedman, Donald B., Kuhn, Max, Chandrasekaran, Ramalakshmi Y.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.81 MB

english, 2013

46

Attention, predictive learning, and the inverse base-rate effect: Evidence from event-related potentials

Wills, Andy J., Lavric, Aureliu, Hemmings, Yvonne, Surrey, Ed

Journal:

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

47

Drug-Induced Mitochondrial Dysfunction || Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons

Dykens, James A., Will, Yvonne

Year:

2008

Language:

english

File:

PDF, 290 KB

english, 2008

48

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

Will, Yvonne, Dykens, James

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2014

Language:

english

File:

PDF, 294 KB

english, 2014

49

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Aleo, Michael D., Luo, Yi, Swiss, Rachel, Bonin, Paul D., Potter, David M., Will, Yvonne

Journal:

Year:

2014

Language:

english

File:

PDF, 631 KB

english, 2014

50

[IEEE 2006 European Conference on Web Services (ECOWS'06) - Zurich, Switzerland (2006.12.4-2006.12.6)] 2006 European Conference on Web Services (ECOWS'06) - Design Patterns for Wrapping Similar Legacy Systems with Common Service Interfaces

Millard, David, Howard, Yvonne, Chennupati, Swapna, Davis, Hugh, Jam, Ehtesham-rasheed, Gilbert, Lester, Wills, Gary

Year:

2006

Language:

english

File:

PDF, 746 KB

english, 2006